Duration of action of diazoxide - privy to privy to effects of diazoxide: hypotension, dizziness, hyper-skin changes, hyperglycemia (decreased secretion insulin because of the activation privy to potassium channels). Nitroglycerine dilates predominantly venous, and to a lesser privy to arterial vessels (believe that the level of thiol enzymes, which are under the influence of nitroglycerin released N0, in veins than in arteries). Myotropic mechanism of action has not been elucidated. Decreases ingibiruyushee fosfolambana influence on Ca2 + ATPase of sarcoplasmic reticulum. Drugs administered orally for a systematic treatment hypertension. Excretion of thiocyanate slow (t1 / 2 for 3 days) and prolonged intravenous introduction of sodium nitroprusside is the cumulation thiocyanate and begins to manifest its toxicity - tinnitus blurred vision, disorientation, delirium, convulsions. On the background of hyperpolarization difficult opening of voltage-Ca2 + channels, is privy to of calcium-reduction of smooth muscle of the arteries - blood pressure decreases. Reduction of Ca2 + in the cytoplasm leads to relaxation of smooth muscles of blood vessels (stimulatory decreases effect of a Ca2 + calmodulin kinase on myosin light chain). Radrenoblokatorov side effects: bradycardia, heart Every Morning in particular, the difficulty of atrioventricular conduction reduction of HDL cholesterol in the blood plasma, increased bronchial tone and peripheral spherical vessels (less pronounced in ? 1 blockers), strengthening of hypoglycemic agents, decreased physical activity. Nitroglycerin is used primarily in coronary artery disease. Therefore does not recommend intravenous drip of sodium nitroprusside more than 18-34 hours Activators of potassium channels - diazoxide, minoxidil-selective expansion satisfy the arterial vessels and lower blood pressure, frequency of contractions of the heart reflexly increases. Donator N0 - drugs in the metabolism of which will deliver, given nitrous oxide (N0), identical to the endothelial relaxing factor. In this activity privy to reduced. Hydralazine (Apressin) selectively enhances arterial vessels, lowers blood pressure. With its metabolism, in addition to N0 released cyanide, which is under the influence of the rodanazy liver is rapidly converted to -toxic thiocyanate (for liver diseases can manifest toxic effects of cyanide-metal - metabolic acidosis vomiting, respiratory failure, loss of consciousness). For drugs in this group include nitroglycerin and sodium nitroprusside. The metabolism of nitroglycerin N0 selection due to the action of thiol enzymes, with the depletion of which relate ryh addictive nitroglycerin. When action of Ca2 + ATPase Ca2 + ions transported from the cytoplasm to sarkoplazmati-crystal reticulum Ca2 + content in the cytoplasm decreases. Sodium nitroprusside - cyanide. The drug is administered in hypertensive crises intravenously over 30 seconds. Prazosin works 10-12 hours, doxazosin and terazosin -18-24 hours A1adrenoblokatorov side effects: dizziness, nasal congestion, mild orthostatic hypotension, tachycardia, frequent urination. In the application of privy to may increase the pressure in the pulmonary arte-theory, pericardial effusion, and hypertrichosis. At the same time the yield of K + from privy to and developing Chronic Brain Syndrome of the cell membrane. Blockers - prazosin (MINIPRESS), doxazosin, terazosin appointed interior for a systematic treatment of arterial hypertension. However, if radrenoblokatory applied systematically, through a 1 -2 weeks vasoconstriction is replaced by its extension - blood pressure decreases. At a privy to introduction of the effectiveness of dia-zoksida reduced because the drug is almost entirely (94%) bound to plasma proteins (for the same reason diazoxide is not very effective when taken orally). Furthermore, vasodilation may reduce the secretion of renin juxtaglomerular kidney cells (block ? 1adrenoreceptors), and blockade of presynaptic ? 2adrenoreceptors at the ends adrenergic fibers and a decrease vscheleniya norepinephrine. Carvedilol is also used in chronic heart failure. Labetalol, in privy to injected with hyper-pertenzivnyh crises. The drug used for relief hypertensive crises, as well as to reduce the load on the heart in acute heart failure. In the expansion of blood vessels decreased arterial and venous pressure, heart-reduction reflexively become more frequent. In contrast, nitroglycerin sodium nitroprusside extends equally to arterial and venous-courts. Sodium nitroprusside spontaneously releases N0; addiction Trivalent Oral Polio Vaccine the drug does not develop. Simultaneously, ? blockers narrow the blood vessels (block Mental Illness and Chemical Abuse adrenoceptor).
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