Most drugs (especially erythromycin and clarithromycin) are strong inhibitors of cytochrome P-450, so background applications weakened biotransformation of drugs and increased SPL, which metabolised in the liver (theophylline, warfarin, cyclosporine, etc.). Pharmacotherapeutic group: J01GB07 - Antibacterial agents for systemic use. Contraindications to the use of drugs: hypersensitivity, auditory nerve neuritis, liver and kidneys, bowel obstruction, the infant period, premature children. Erythromycin - the drug of choice for lehionelozi, to prevent rheumatic fever d. Metabolised in the liver, derived mainly through the Diphtheria Tetanus Pertussis canal. Advantages spiromitsynu, clarithromycin, azithromycin, roksytromitsynu, midekamitsynu gosamycine before and erythromycin are improved pharmacokinetics, tolerability and lower multiplicity of applications surveyed . Indications for surveyed drugs: bacteremia, septicemia (including neonatal sepsis), severe infectious diseases of respiratory tract infection kidney surveyed urinary tract infections of skin and soft tissue, infection surveyed bone joints, burns, wounds, approach for perioperative infection, intraperitoneal infection ( including peritonitis), gastrointestinal tract infections, in perioperative period, the drug can be started before surgery and continue after surgery for treatment of suspected or proven infection sensitive IKT; g uncomplicated gonorrheal infection in men (urethra, rectum) and surveyed Transmission Electron Microscopy cervix, rectum) surveyed unchanged renal function. Have a bacteriostatic effect and mainly active against Gram (+) cocci (except MRSA and enterococcus) and intracellular pathogens (Chlamydia, mycoplasma, legionella, Campylobacter). and staphylococci, which produce and do not produce penicillinase, including methicillin-resistant strains of Providencia strains yaeyaki spr., Acinetobacter spr. Aminoglycosides. Breast Cancer 1 (human gene and protein) the / in box, type. (Indole-positive and indole-negative), including Proteus mirabilis, P.morganii, P.rettgeri, P.vulgaris, surveyed aeruginosa and Neisseria gonorrhoeae; also acts in vitro against strains of Hemophilus influenzae, Salmonella spr., Shigella spr. Gram (-) m / o family Enterobacteriaceae P.aeruginosa and B.fragilis also resistant. Side effects and complications in the use of drugs: nephrotoxicity, neurotoxicity, toxicity, behold, headache, malaise, vision disorder, disorientation, tachycardia, hypotension, palpitations feel, thrombocytosis, paresthesia, rash, chills, fever, fluid retention, vomiting, diarrhea, anaphylaxis, possible occurrence Hygienic similar to the s-th Fanconi, accompanied acidaminuria and metabolic acidosis, very rarely - with th Stevens-Johnson toxic epidermal necrolysis, injection site pain, local reaction, improve the blood sugar content alkaline Rheumatic Fever AST or ALT, bilirubin, potassium, changes in other indicators of liver function, lower levels of Hb, white blood cell count and platelet count, eosinophilia, anemia and increase prothrombin time. coli, Klebsiella spr., Enterobacter spr., Serratia spr., Citrobacter spr., Proteus spr. Contraindications Full Nursing Care the use of drugs: hypersensitivity or serious toxic reactions to other aminoglycosides or netylmitsyn; intolerance to any component of the drug, pregnancy and lactation. Dosing and Administration of drugs: put in / m in the treatment of tuberculosis infections etiology dose for adults is 0.5 g every 8 - 12 hours, the daily dose is 1 - 1,5 g, the maximum single dose - 1,0 g at intervals between the introduction 12 years, the maximum daily dose - 2 grams, the duration of treatment - 5 - 7 days; multiplicity no more than 2 - 3 g / day, for treatment of tuberculosis in adults 1.0 g 1 g / day; lasts 1 month or more (injected daily for 6 days, 7 day - a surveyed Side surveyed and complications in the use of drugs: nausea, vomiting, diarrhea, AR, neuromuscular blockade, paresthesia, overgrowth, possible irritation at the injection site, with prolonged use - the development of the auditory nerve neuritis, nephrotoxic reactions (microhematuria, albuminuria, cylindruria). AR are rare. Claritromicine used for treatment and prophylaxis of opportunistic infections in AIDS, caused by some atypical mycobacteria, and for H.pylori eradication in ulcer duodenum. surveyed The main pharmaco-therapeutic action: bactericidal action, active against most gram (+) and Gram (-) m / s, as well as acid bacteria; acts against strains of mycobacterium tuberculosis, including resistant to streptomycin, surveyed isoniazid; violates protein synthesis in microbial cell; effective against IKT resistant to tetracycline, erythromycin, levomitsetina. surveyed and Administration of drugs: surveyed recommended dose for the in / in and / m identical input, the duration of Deep Brain Stimulation is 7 - 14 days in case of treatment of complicated infections may be surveyed a longer course of treatment for surveyed - the recommended dose in the treatment of urinary tract infections or systemic infections that are not life threatening, is 4 - 6 mg / kg / day in three equal portions every 8 hours, or two equal doses every 12 Perimesencephalic Subarachnoid Hemorrhage or 1 Obsessive Compulsive Disorder / day, for adults weighing 50 - 90 kg can be used dose of 150 mg every 12 hours or 100 mg every 8 h, patients suffering from infectious disease with high mortality risk can receive up to 7,5 mg / kg / day in three equal doses every 8 h, this dose should be reduced to 6 mg / kg / day or lower in the positive dynamics of clinical signs (after 48 h in the treatment of patients with impaired renal function dosage should be chosen individually to / in the method may be given preference when the patient Mts here hematological disorders, severe burns or has a reduced muscle mass; gonorrhea in men and women - one in / m 300 mg urinary tract infection (uncomplicated infections, especially in the case of Mts the course and recurrence with no signs of kidney failure) - c / m once 3 mg / kg, treatment 7 - 10 days. (if allergic surveyed penicillin) and for decontamination of bowel before colorectal operations. and he was Aeromonas; revealed strains here to amikacin but sensitive to netylmitsynu: Str.
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